FRA Gut Balance is able to replace preventive antibiotic usage

Trial results show that FRA Gut Balance can be applied to successfully replace the preventive usage of antibiotics in broiler rabbits. At a commercial farm in Eastern Europe, FRA Gut Balance was administered to replace the antibiotic valnemulin.

Valnemulin is an antibiotic that is used in broiler rabbits to reduce mortality rates during an outbreak of Epizootic Rabbit Enteropathy (ERE). During ERE outbreaks, rabbits reduce their feed and water intake which can lead to both dehydration and weight loss. Clostridium perfringens and Escherichia coli are frequently detected in the small intestine and in faecal samples from rabbits suffering from ERE.

Another study showed an overgrowth of Bacteroides fragilis, Clostridium perfringens, Enterobacter sakazakii and Akkermansia muciniphila and inhibition of Bifidobacterium spp. and Butyrivibrio fibrisolvens in the stomach, small intestine and caecum. Although published studies are inconclusive about the specific bacteria involved, it is generally assumed that there is some form of microbial origin associated with the development of ERE. Furthermore, a disbalance in the microbiota may play an important role in the onset of ERE.

FRA Gut Balance

Glycerides have strong anti-microbial properties against pathogenic Gram-negative and Gram-positive bacteria. When it is not clear if a bacterial challenge originates from a Gram-negative or Gram-positive bacteria, a broad-spectrum antibacterial effect is required. FRA Gut Balance contains glycerides of short- and medium chain fatty acids and is designed to overcome a wide range of bacterial challenges.

Results in broiler rabbits

At a commercial fattening farm in Hungary, FRA Gut Balance was applied to replace valnemulin at 440 ppm. Rabbits receiving FRA Gut Balance gained 2.2% more weight in the weaning period compared to rabbits in the control group. Feed intake was reduced with 2.4% in the treatment group and FCR was improved by 14 points when FRA Gut Balance was administered instead of valnemulin. The mortality for all rabbits in this trial was 2.43% in the control group and 1.04% in the treatment group. Hence, mortality was reduced by 57.2% when FRA Gut Balance was administered to the diet compared to the antibiotic valnemulin.


The trial indicates that FRA Gut Balance is able to successfully replace the preventive usage of antibiotics in broiler rabbits. FRA Gut Balance even improved performance parameters in the weaning period as indicated by a higher ADWG, lower FCR and reduced mortality. FCR was improved with 14 points in the treatment group and mortality was clearly reduced by more than 57%.

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