Effective Pathogen Control with FRA Gut Balance

Broilers receiving FRA Gut Balance in their diet grow faster and more efficient. This feed additive shows results with significantly higher final body weight. The improved performance and economical advantage are attributed to effective pathogen control by the carefully selected glycerides combination in FRA Gut Balance.

The use of antibiotic growth promoters is restricted in many countries worldwide. As a substitute, feed suppliers have mainly focused on adding organic acids or their salts. And with success, because these organic acids are well known for their positive effect on intestinal health and growth performance.

The innovative alternative: Glycerides

Since quite some years, researchers are convinced that even better results can be achieved with organic acids when administered in a new, innovative form. That is why FRAmelco developed FRA Gut Balance, consisting of carefully selected glycerides of conventional organic acids as: propionic acid, butyric acid, caprylic acid and capric acid. While the free form only acts in the acid environment of the stomach, research shows that glycerides of these organic acids, also have effect in the lower parts of the intestinal tract. Moreover, they possess much stronger antibacterial effects.

Pathogen Control

Why expect better growth results in broilers receiving FRA Gut Balance? Broilers face various bacterial challenges in daily practice, varying from Gram-positive, such as Clostridium perfringens, Streptococcus suis and Enterococcus, and Gram-negative bacteria, such as Escherichia coli and Salmonella. In the battle against both types of bacteria, it is important to be aware of the differences in their structure. This means that a diverse approach is needed to inhibit their growth and potentially kill them.

Gram-positive bacteria typically have a simple membrane structure. The molecules that construct bacterial membranes and glycerides of organic acids are both amphiphilic by nature. Therefore, they can easily interfere with each other. Glycerides will settle in the bacterial membrane, disrupting its structure. Especially glycerides of medium chain fatty acids are known to be effective against Gram-positive bacteria.

Gram-negative bacteria, such as E. Coli and Salmonella, have more complex inner and outer membrane structures, making disruption of the cell membrane more difficult. Still, glycerides can enter the bacteria – like organic acids do – and alternate the DNA structure of the bacteria from the inside. After that, the cell loses its ability to produce invading proteins and infect the host. Especially glycerides of short chain fatty acids are highly effective against Gram-negative bacteria.

FRA Gut Balance is designed to balance the intestinal microbiota and to promote overall gut health and zootechnical performances. It is a promising tool to replace antibiotics in animal feed.

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